Introducing physical exercise as a potential strategy in liver cancer prevention and development

There are many evidences about benefits of physical activity which are mostly related to the metabolism regulation and body health. Deeper investigation deals with other features of physical activity such as anticancer property. Aim. In this study, anticancer property of physical activity investigates via network analysis in the trained rats.Methods. To investigate proteome profile of rats’ liver subjected to physical activity via bioinformatics, protein-protein interaction network analysis was applied. For this reason, a number of 12 differentially expressed proteins were searched and analyzed by Cytoscape 3.7.2 and its plug-ins. The network was analyzed to identify hub-bottleneck nodes. The action map was constructed for the central proteins. Results. The findings indicate that among the queried proteins, Eno1 and Pgm1 were only assigned as hubs by Network Analzyer. Gpi, Pkm, Aldoa, and Aldoart2 also were identified ad central nodes among the first neighbors of network elements. Furthermore, glycolytic process, carbohydrate catabolic process, and glucose metabolic process are the enrichment of key elements that could be imperative in the mechanism of exercise in liver function. Anticancer property of the central nodes was highlighted. Conclusion. Our network findings point out the anticancer properties of physical activity, which was also supported by the previous investigations.