Author/Authors :
Hamzeloo-Moghadam, Maryam Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy - School of Traditional Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rezaei Tavirani, Mostafa Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Jahani-Sherafat, Somayeh Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Esmaeil, Somayeh Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy - School of Traditional Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ansari, Mojtaba Proteomics Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ahmadzadeh, Alireza Proteomics Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Omeprazole as a proton pump inhibitor has a widespread consumption to inhibit gastric acid secretion. Assessment of omeprazole effects on human cardiovascular system is the main aim of this study.
Methods: Gene expression profiles of “human coronary artery endothelial cells” in the absence and presence of omeprazole is downloaded from gene expression omnibus (GEO). The differentially expressed genes (DEGs) are interacted as an interactome and the hub nodes are determined. The DEGs are enriched via gene ontology (GO) analysis. The critical hubs are identified based on GO finding.
Results: Among 103 queried DEGs 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes are identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.
Conclusion: In conclusion, long time consumption of omeprazole may be accompanied with undesirable effects, however more evidences are required.
