Author/Authors :
Kumar, Amit Shoolini University of Biotechnology and Management Sciences - Dept of Biotechnology, India , Thakur, Suresh Shoolini Institute of Life Sciences and Business Management, India , Thakur, Vishal Chand Shoolini Institute of Life Sciences and Business Management, India , Kumar, Ajay Shoolini Institute of Life Sciences and Business Management, India , Patil, Sandip Shoolini University of Biotechnology and Management Sciences - Dept of Biotechnology, India , Vohra, M.P Shoolini Institute of Life Sciences and Business Management, India
Abstract :
Background: Candida is a part of normal microflora of human body and exists as an opportunistic pathogen as it attacks immunocompromised patients. Aims and Objectives: Candida is the most commonly isolated organism from blood stream infections. Fluconazole is the major antifungal drug used for treatment of Candida. Resistance to fluconazole has been increasing in recent years so there should be search of some other alternative. To find out these alternatives, anti candidial activity of some natural essential oils was studied. Materials and Methods: In the present study nine Candida strains isolated from blood stream infections were collected from National Culture Collection of Pathogenic Fungi (N.C.C.P.F.) P.G.I.M.E.R Chandigarh India and the antifungal activity of some natural essential oils such as lemongrass oil, coconut oil, almond oil and clove oil was checked by using agar diffusion method. Result: All oils have shown a significantly anti-candidal activity. However, the antifungal activity was maximum in lemongrass oil. Conclusion: Our study may help to design new chemotherapeutic strategies against Candidal infections
Keywords :
Candida , Blood stream , Lemon grass oil , Antifungal activity
