Elaboration of impregnated guava seed by Cu(II) for fixing glimepiride using Square-wave Adsorptive Stripping Voltammetry

A simple and novel adsorbent has been developed for the determination of glimepiride (Glim) drug in aqueous media. This adsorbent is prepared by impregnation of guava seed with Cu(II) (GS-Cu). The effect of different parameters such as effect of pH, amount of adsorbent and drug concentrations on the adsorption process is studied. Point zero charges for this adsorbent (GS-Cu) is determined and found to be 4.1. The adsorption percent of Glim using GS-Cu reach to 99.8 % at pH = 4.0. Limit of detection (LOD) and limit of quantitation (LOQ) were found to be 3.4 and 7.7 μg mL^–1, respectively for Glim using GS-Cu. The proposed method was used successfully for Glim determination in environmental water samples with high recovery values.