The Potential Anti-Inflammatory Effects of Zerumbone in COVID-19 Patients

Coronavirus disease 2019 (COVID-19) pandemic started in Wuhan (China) in December 2019 and spread rapidly to become a global health and economic emergency. A powerful inflammatory response to Se-vere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is thought to be the leading cause of disease severity and death in patients with COVID-19, which is associated with high levels of circulating cy-tokines, profound lymphopenia, and significant mono-nuclear cell infiltration in different organs like lungs, heart, spleen lymph nodes, and kidney 1. Zerumbone (ZER), which is mainly isolated from the rhizomes of Zingiber zerumbet (Z. zerumbet), was found to be ef-fective against inflammatory and immune disorders. Different studies demonstrated that ZER suppressed the production of pro-inflammatory cytokines in can-cerous tissues and several immune cells 2. Therefore, the successful control of inflammatory state would be a promising approach for the management of COVID-19 and the use of therapeutics that modulate inflammation without compromising the adaptive immune response could be the most effective therapeutic strategy. There-fore, the aim of this study was to investigate COVID-19 and ZER relationships through the inflammatory cytokines....