Author/Authors :
Bahadori, Moslem Distinguished Professor of Pathology - Tehran University of Medical Sciences - Academy of Medical Sciences, Tehran, Iran , Dabiri, Shahriar Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Javadi, Abdolreza Department of Pathology - Shaid Beheshti University of Medical Sciences, Tehran, Iran , Shamsi Meymandi, Simin Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Movahedinia, Sajjadeh Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Shamsi Meymandi, Manzumeh Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - K , Khorasani, Parisa Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Farrokhnia, Mehrdad Infectious and Internal Medicine Department - Afzalipour Hospital - Kerman University of Medical Sciences, Kerman, Iran , Yousefi, Meysam Infectious and Internal Medicine Department - Afzalipour Hospital - Kerman University of Medical Sciences, Kerman, Iran , Sarrafzadeh, Farhad Infectious and Internal Medicine Department - Afzalipour Hospital - Kerman University of Medical Sciences, Kerman, Iran , Abosaidi, Hamid Infectious and Internal Medicine Department - Afzalipour Hospital - Kerman University of Medical Sciences, Kerman, Iran , Shojaeepour, Saeedeh Department of Pathology - Shaid Beheshti University of Medical Sciences, Tehran, Iran , Mortazaizadeh, Abbas Department of Pathology - Shaid Beheshti University of Medical Sciences, Tehran, Iran , Rezaei, Mitra Department of Pathology - Shaid Beheshti University of Medical Sciences, Tehran, Iran , Dabiri, Bahram Department of Pathology - Resident NYU Langone Health, Mineloa, NY, USA , Mohabati, Nader Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Ranjbar, Hanie Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Rashidinejad, Sara Department of Pathology - Pathology and Stem Cells Research Center - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Feizy, Abdolamir Department of Pathology - Zanjan University of Medical Sciences, Zanjan, Iran
Abstract :
The pathogenesis of the COVID19 pandemic, that has killed one million nine hundred people and infected more the 90 million until end of 2020, has been studied by many researchers. Here, we try to explain its biological behavior based on our recent autopsy information and review of literature.
Methods: In this study, patients with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) result were considered eligible for enrollment. Histopathological examinations were done on 13 people who were hospitalized in Afzalipour hospital, Kerman, Iran. Clinical and laboratory data were reviewed. Tissue examination was done by light microscopy, immunohistochemistry and electron microscopy.
Results: The most frequent co-morbidity in the patients was cardiovascular disease. The common initial symptoms of COVID-19 infection were dyspnea and cough. In all cases, the number of white blood cells was higher than the normal range. Common histopathological findings were variable degrees of vasculitis as degenerative to necrotic changes of endothelium and trafficking of inflammatory cells in the vessel wall with fibrinoid necrosis. Tissue damage included interstitial acute inflammatory cells reaction with degenerative to necrotic changes of the parenchymal cells. CD34 and Factor VIII immunohistochemistry staining showed endothelial cell degeneration to necrosis at the vessel wall and infiltration by inflammatory cells. Electron microscopic features confirmed the degenerative damages in the endothelial cells.
Conclusion: Our histopathological studies suggest that the main focus of the viral damage is the endothelial cells (endotheliopathica) in involved organs. Also, our findings suggest that degeneration of leukocytes occurs at the site of inflammation and release of cytokines (leukocytoclastica) resulting in a cytokine storm.
