Title of article :
Azole Antifungal Resistance in Candida albicans and Candida glabrata Isolated from Vulvovaginal Candidiasis Patients
Author/Authors :
Deravi, Niloofar Medical Student Research - School of Medicine - Shahid Beheshti University of Medical Sciences , Fathi, Mobina Medical Student Research - School of Medicine - Shahid Beheshti University of Medical Sciences , Tabatabaeifar, Nadia Department of Internal Medicine - Sina Hospital - Tehran University of Medical Sciences , Pooransari, Parichehr Department of Obstetrics and Gynecology - Shohada Hospital - Shahid Beheshti University of Medical Sciences , Ahmadi, Bahram Department of Medical Laboratory Sciences - School of Para-Medicine - Bushehr University of Medical Sciences , Shokoohi, Gholam Reza Department of Medical Parasitology and Mycology - School of Medicine - Jahrom University of Medical Sciences , Yaghoobpoor, Shirin Medical Student Research - School of Medicine - Shahid Beheshti University of Medical Sciences , Vakili, Kimia Medical Student Research - School of Medicine - Shahid Beheshti University of Medical Sciences , Lotfali, Ensieh Department of Medical Parasitology and Mycology - School of Medicine - Shahid Beheshti University of Medical Sciences , Ansari, Saham Department of Medical Parasitology and Mycology - School of Medicine - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Vulvovaginal candidiasis (VVC) is the most frequent fungal disorder in healthy and normal women. Objectives: The aim of this study was to evaluate the in vitro antifungal susceptibility of clinical isolates Candida albicans and Candida glabrata, the two most common candida species in Iranian patients with VVC. Methods: One hundred and eight clinical isolates of candida, including; C. albicans (n = 77) and C. glabrata: (n = 31) were isolated from the 108 patients with VVC. The in vitro activity of caspofungin (CAS), amphotericin B (AMB), voriconazole (VRC), itraconazole (ITC), fluconazole (FLC), and nystatin (NYS) were determined according to the CLSI M27-A3 and CLSI M27-S4. Results: Our results wereshown8 (25. 8 %) and 6 (7. 8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8. 4%, and 3. 7% of all isolates, and six isolates (5. 6%) had intermediate MIC to CAS. Conclusions: We reported 8 (25. 8 %) and 6 (7. 8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8. 4% and 3. 7% of all isolates, respectively.
Keywords :
Antifungal Susceptibility , Candida albicans , Candida glabrata , Vulvovaginal Candidiasis
Journal title :
Archives of Clinical Infectious Diseases
