Author/Authors :
Amirkhanlou, Saeid Department of Nephrology - Clinical Research Development Unit - Sayad Shirazi Hospital - Golestan University of Medical Sciences, Gorgan, Iran , Roshandel, Gholamreza Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences, Gorgan, Iran , Aghaei, Mehrdad Center (JBCRC) Golestan University of Medical Sciences, Gorgan, Iran , Mohebi, Hossein Department of Orthopedic Surgery - Kermanshah University of Medical Sciences, Kermanshah, Iran , Tabatabei, Sahab-Sadat Department of Internal Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Momen, Shiva Student Research Committee - School of Pharmacy - Mazandaran University of Medical Sciences, Sari, Iran , Zia, Peyman Department of Orthopedic Surgery - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Aarabi, Mehdi Department of Orthopedic Surgery - Toronto East General Hospital - University Health Network, Toronto, Ontario, Canada , Amouzadeh, Farzad Emem-Hossein Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hosseininejad, Mohsen Bone Joint and Related Tissues Research Cente - Akhtar Orthopedic Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
End-stage renal disease (ESRD) is a condition in which bone turnover and metabolism is impaired; thus, osteoporosis and low bone density are subsequently inevitable. We aimed to determine bone mineral density (BMD) and biochemical markers, and associated factors in hemodialysis (HD) patients.
Methods: Patients aged 30-70 years undergoing HD between 2015 to 2019 were enrolled in this cross-sectional study. BMD measured by dual energy x-ray absorptiometry (DEXA) and biochemical laboratory tests were assessed in 200 patients undergoing HD. Statistical analysis was based on t test, Pearson, regression and Mann-Whitney tests using SPSS 16.
Results: Two hundred patients were investigated. Sixty percent of the patients were female. Mean ± SD of participants’ age was 58.6 (±11.63) years and mean ± SD for duration of HD was 45.69 (± 43.76) months. Osteoporosis was found in 48% (n=96) and low bone density in 36% (n=76) of our patients. General osteoporosis was more frequent in those undergoing HD for more than 3 years, although not significantly (P=0.093, odds ratio [OR]=0.37). However, regional osteoporosis in hip and femoral neck, but not spine vertebrae, were significantly higher after three years of HD (P=0.036, OR=0.27; P=0.042, OR=0.27; and P=0.344, OR=0.56, respectively). Increased body mass index (BMI) correlated negatively with osteoporosis (P=0.050).Conclusion: With increasing age and duration of HD, BMD decreases. Higher BMI was associated with higher bone mass density. Bone density assessment seems to be necessary in patients undergoing HD.
Keywords :
Biomarkers , Risk factors , Renal dialysis , Osteoporosis , Bone mineral density
