Author/Authors :
Pourmobini, H Immunology of Infectious Diseases Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Kazemi Arababadi, Mohammad Department of Immunology - Faculty of Medicine - Immunology of Infectious Diseases Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Salahshoor, Mohammad Reza Department of Anatomical Sciences - Medical School - Kermanshah University of Medical Sciences - Kermanshah, Iran , Roshankhah, Sh Department of Anatomical Sciences - Medical School - Kermanshah University of Medical Sciences - Kermanshah, Iran , Taghavi, Mohammad Mohsen Department of Anatomy - Faculty of Medicine - Social Determinants of Health Research center Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Taghipour, Z Department of Anatomy - Faculty of Medicine - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Shabanizadeh, A Department of Anatomy - Faculty of Medicine - Immunology of Infectious Diseases Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran
Abstract :
Royal jelly (RJ) is a honey bee product for which, antiinflammatory
properties were shown in vitro. Nanoparticles,
including nano-silver (NS), are plausible inflammation inducers
that act by activation of immune cells and consequent production of
pro-inflammatory cytokines. This project aimed to explore
immunomodulatory effects of royal jelly and nano-silver on the
kidney and liver.
Materials and Methods: In this project, 40 male rats were grouped
as follows: 10 rats as controls, 10 rats treated with RJ; 10 rats treated
with both NS and RJ and 10 rats treated with NS. Liver and kidney
interleukin (IL)-1β, -2, -6, and -33 levels were determined using
commercial ELISA kits.
Results: RJ reduced kidney IL-6 levels in comparison to control
and NS--RJ groups. RJ and NS reduced kidney and liver IL-1β
levels. Kidney IL-33 levels were decreased in the RJ and nanosilver
groups in comparison to the NS--RJ group.
Conclusion: Based on this study, it may be concluded that RJ
together with NS can play anti-inflammatory roles and may affect
the function of immune cells.
Keywords :
Kidney , Liver , Nano-silver , Royal jelly
