Title of article :
The Effect of Chemotherapy in Gestational Trophoblastic Disease on Infertility: A Review on Pathophysiologic Mechanism
Author/Authors :
Eslamnik, Parvinsadat Department of Obstetrics and Gynecology - School of Medicine - Yasuj University of Medical Sciences , Moghaddasi, Mana Department of Biology - Payame Noor University (PUN) , Malmir, Ali Department of Cell and Molecular Biology - Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, , Sadeghi-Goughari, Bahar department of Obstetrics and Gynecology - Akbarabadi Hospital - Iran University of Medical of Sciences , Javan, Mohammad Reza blood Transfusion Research Center - High Institute for Research and Education in Transfusion Medicine , Ebrahimi, Maryam department of Obstetrics and Gynecology - Akbarabadi Hospital - Iran University of Medical of Sciences
Abstract :
Today, young women infertility through chemotherapy has become a global challenge. chemotherapy destructs the malignant cells by reactive oxygen species (ros) production and inflammatory factors secretion; these factors can also destruct the ovarian and uterine cells. infertility usually happens as a result of ovarian and uterine cells apoptosis, as well as dysfunction in these organs. signaling pathways activated by chemotherapy lead to increased activation of follicles and depletion of the follicular pool. in addition, excessive secretion of sex hormones leads to follicles activation and infertility in women. mesenchymal stem cells (msc) use have been reported to be a great help in restoring the function of ovarian and uterine cells. on the other hand, they can regulate sex hormone secretion. finally, the use of mscs as a suitable treatment strategy can help restore the function of reproductive cells and treat infertility.
Keywords :
Chemotherapy , Infertility , Gestational Trophoblastic Disease , Premature Ovarian Failure , Mesenchymal Stem Cell
Journal title :
Archives of Medical Laboratory Sciences
