Title of article :
Added diagnostic value of SPECT to evaluate bone metastases in breast cancer patients with normal whole body bone scan
Author/Authors :
Abedi, Mohammad Department of Radiology and Nuclear Medicine - Faculty of Medicine - Cardiovascular Research Center - Mazandaran University of Medical Sciences, Sari , Mardanshahi, Alireza Department of Radiology and Nuclear Medicine - Faculty of Medicine - Cardiovascular Research Center - Mazandaran University of Medical Sciences, Sari , Zeanali, Reza Faculty of Medicine - Mazandaran University of Medical Sciences, Sari
Abstract :
Background: In this research, we aimed to survey the added value of single photon emission
computed tomography (SPECT) in comparison with planar whole body bone scan to
visualize bone metastatic lesions in patients with breast cancer.
Methods: A total of 80 patients with breast cancer (invasive ductal carcinoma) were
examined with planar whole body bone scan and SPECT imaging using 99mTc-labelled
methylene diphosphonate (99mTc-MDP). The patients with abnormal uptakes in SPECT
imaging were also investigated with magnetic resonance imaging (MRI).
Results: Among these 80 patients with normal whole body bone SPECT scan, 19 (23.25%)
of them revealed abnormal 99mTc-MDP uptake in skeleton. Furthermore, these 19 patients
were subjected to MRI and 3 (3.75%) of them were confirmed with metastatic bone lesion.
Conclusion: The obtained data suggest that SPECT possess the added diagnostic over planar
whole body bone scan.
Keywords :
99mTc-MDP , SPECT , Whole body bone scan , Breast cancer , Bone metastasis
Journal title :
Caspian Journal of Internal Medicine (CJIM)
