Author/Authors :
Suryakusumah, Lingga Internal Medicine Department - Faculty of Medicine - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Ahmad Tabri, Nur Division of Pulmonology and Respiratory - Department of Internal Medicine - Faculty of Medicine - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Saleh, Sahyuddin Division of Hematology and Medical Oncology - Department of Internal Medicine - Faculty of Medicine - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Bakri, Syakib Internal Medicine Department - Faculty of Medicine - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Kasim, Hasyim Internal Medicine Department - Faculty of Medicine - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Fachruddin Benyamin, Andi Division of Hematology and Medical Oncology - Department of Internal Medicine - Faculty of Medicine - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Arief, Erwin Division of Pulmonology and Respiratory - Department of Internal Medicine - Faculty of Medicine - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Seweng, Arifin Biostatistics Department - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia
Abstract :
Background: Tuberculosis (TB) is an infectious disease caused by mycobacterium
tuberculosis (Mtb). This infection causes the release of proinflammatory cytokines that
affect hemostasis. Pulmonary TB infection causes an increased activation of procoagulant
factors, decreased anticoagulant factors and suppresses fibrinolysis which causes
hypercoagulable. Our study is conducted to assess the association between pulmonary TB
infection (PTB) with hemostatic parameters before and after intensive phase treatment.
Methods: This was an analytic observational prospective cohort design. The study was
conducted at the Community Center for Lung Health in South Sulawesi. Studied subjects
were recruited by consecutive sampling, in which the patients who met the inclusion criteria
received intensive phase of ATD treatment. PT, aPTT, fibrinogen, and D-dimer were
measured before treatment and after the intensive phase of ATD. These data were analyzed
using the SPSS Version 22.
Results: In this study, 30 subjects are new cases of PTB. Prothrombin time, aPTT and D-
dimer levels were higher in far advanced lesions and smear-positive sputum group
(p<0.001). There was a significant level decrease in PT, aPTT, fibrinogen, D-dimer after
intensive phase treatment (p<0.001).
Conclusion: Pulmonary tuberculosis infection is associated with hypercoagulability which
is characterized by an increase in hemostatic parameters and has significant improvement
after intensive phase of ATD treatment.
