Celiac Disease and Other Autoimmune Manifestations in a Nine-Year- Old Girl

Celiac disease is an autoimmune disease with a high incidence of multi-organ involvement; particularly, gastrointestinal manifestations and a doubled risk of malignancies. Here, we report a case of celiac disease with autoimmune hemolytic anemia (AIHA). A nine-year-old girl presented to us with a history of abdominal pain, fever, nausea, and vomiting. Her examination findings were pallor and splenomegaly; her laboratory tests showed increased liver enzymes and macrocytosis with positive Coombs without a decrease in hemoglobin or high reticulocyte count. Poly-autoimmunity was considered, and AIHA and celiac disease were diagnosed throughout the admission following an in-depth workup. The patient responded to a strict gluten-free diet and pulse corticosteroids. This was a rare case of celiac disease presenting with such an array of signs and symptoms, with management also being distinctive and challenging.