Title of article :
Does Prior Immunization with Measles, Mumps, and Rubella Vaccines Affect the Antibody Response to COVID-19 Antigens ?
Author/Authors :
Hassani, Danesh Department of Immunology - School of Public Health - Tehran University of Medical Sciences - Tehran, Iran , Amiri, Mohammad Mehdi Department of Immunology - School of Public Health - Tehran University of Medical Sciences - Tehran, Iran , Maghsood, Faezeh Department of Immunology - School of Public Health - Tehran University of Medical Sciences - Tehran, Iran , Salimi, Vahid Department of Virology - School of Public Health - Tehran University of Medical Sciences - Tehran, Iran , Kardar, Gholam Ali Immunology Asthma & Allergy Research Institute - Children’s Medical Center - Tehran University of Medical Sciences - Tehran, Iran , Barati, Omid Health Human Resources Research Center - School of Management and Medical Informatics - Shiraz University of Medical Sciences - Shiraz, Iran , Hashemian, Mohammad Reza Chronic Respiratory Diseases Research Center (CRDRC) - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Jeddi-Tehrani, Mahmood Monoclonal Antibody Research Center - Avicenna Research Institute - ACECR - Tehran, Iran , Zarnani, Amir-Hassan Department of Immunology - School of Public Health - Tehran University of Medical Sciences - Tehran, Iran , Shokri, Fazel Department of Immunology - School of Public Health - Tehran University of Medical Sciences - Tehran, Iran
Abstract :
Incidence and severity of SARS-CoV2 infection are
significantly lower in children and teenagers proposing that certain
vaccines, routinely administered to neonates and children may
provide cross-protection against this emerging infection.
Objective: To assess the cross-protection induced by prior measles,
mumps and rubella (MMR) vaccinations against COVID-19.
Methods: The antibody responses to MMR and tetanus vaccines
were determined in 53 patients affected with SARS-CoV2 infection
and 52 age-matched healthy subjects. Serum levels of antibodies
specific for NP and RBD of SARS-CoV2 were also determined in
both groups of subjects with ELISA.
Results: Our results revealed significant differences in anti-NP
(P<0.0001) and anti-RBD (P<0.0001) IgG levels between patients
and healthy controls. While the levels of rubella- and mumpsspecific
IgG were not different in the two groups of subjects,
measles-specific IgG was significantly higher in patients (P<0.01).
The serum titer of anti-tetanus antibody, however, was significantly
lower in patients compared to healthy individuals (P<0.01).
Conclusion: Our findings suggest that measles vaccination trigger
those B cells cross-reactive with SARS-CoV2 antigens leading to
production of increased levels of measles-specific IgG.
Keywords :
Tetanus , SARS-CoV2 , MMR , Cross-protection , Antibody response
