Title of article
Mast Cell Numbers in Primary Eosinophilic Colitis Are Significantly Higher Than in Secondary Tissue Eosinophilia and Normal Controls: A Possible Link to Pathogenesis
Author/Authors
Awad, Heyam Microbiology and Forensic Medicine Department - Histopathology - University of Jordan , Sfaira, Ammar Department of Lab Medicine - Jordan University Hospital, Jordan , Abu Osba, Yousef Department of Lab Medicine - Jordan University Hospital, Jordan , Shahin, Mohammad School of medicine - University of Jordan - Amman, Jordan , Al- Asa'd , Yousef Microbiology and Forensic Medicine Department - Histopathology - University of Jordan , Isbeih, Nooredeen Microbiology and Forensic Medicine Department - Histopathology - University of Jordan , Shomaf, Maha Microbiology and Forensic Medicine Department - Histopathology - University of Jordan , Hayagneh, Wasan Microbiology and Forensic Medicine Department - Histopathology - University of Jordan
Pages
10
From page
220
To page
229
Abstract
Primary Eosinophilic Colitis (PEC) is one of the
rare eosinophilic gastrointestinal diseases with a poorly understood
pathogenesis. Eosinophilic esophagitis (EE) is the most common
and best-understood disease in this category. Activated mast cells
(MCs) have a role to play in the tissue damage in EE. It is not known
if PEC shares this mechanism.
Objective: This cross-sectional study aimed to investigate the
number of MCs in PEC and to compare them with cases of secondary
colonic tissue eosinophilia (TE) and normal colon.
Methods: The study included 19 PEC cases, 47 cases of secondary
tissue eosinophilia and 50 normal colon tissues. Histopathological
slides of all cases were reviewed to confirm the diagnosis and count
the number of eosinophils. Glass slides for all cases were stained for
C-kit (CD117) to highlight and count the MCs.
Results: The mean number of the MCs in normal controls was 9.7
MCs per HPF (SD=4.6). The mean number of MCs in the PEC
cases was 26.5 (SD=7.1) which was significantly higher than the
normal counts (p-value <0.000). The mean number of MCs in the
secondary TE group was 18.0 (SD=7.1), whichwas significantly
higher than normal controls; P<0.000. Comparing MC counts in
PEC and secondary TE also revealed a significant difference with a
P value of <0.000.
Conclusion: MCs in PEC are significantly higher than those in
secondary TE and normal controls. This suggests the role of the
MCs in the pathogenesis of Primary Eosinophilic Colitis
Keywords
Mast Cells , Gastrointestinal Diseases , Eosinophilic Colitis , Eosinophilia
Journal title
Iranian Journal of Immunology (IJI)
Serial Year
2021
Record number
2701548
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