Author/Authors :
Stojanovic, Maja Clinic of Allergy and Immunology - Clinical Center of Serbia - Belgrade - Serbia - Faculty of Medicine - University of Belgrade - Belgrade, Serbia , Andric, Zorana Tissue Typing Department - Blood Transfusion Institute of Serbia - Belgrade, Serbia , Popadic, Dusan Institute of Microbiology and Immunology - Faculty of Medicine - University of Belgrade - Belgrade, Serbia , Stankovic Stanojevic, Marija Department of Pathophysiology - Faculty of Medicine - University of Belgrade - Belgrade, Serbia , Miskovic, Rada Clinic of Allergy and Immunology - Clinical Center of Serbia - Belgrade - Serbia - Faculty of Medicine - University of Belgrade - Belgrade, Serbia , Jovanovic, Dragana Clinic of Allergy and Immunology Clinical Center of Serbia - Belgrade, Serbia , Popadic, Aleksandra Peric Clinic of Allergy and Immunology - Clinical Center of Serbia - Belgrade - Serbia - Faculty of Medicine - University of Belgrade - Belgrade, Serbia , Bolpacic, Jasna Clinic of Allergy and Immunology - Clinical Center of Serbia - Belgrade - Serbia - Faculty of Medicine - University of Belgrade - Belgrade, Serbia , Tomic-Spiric, Vesna Clinic of Allergy and Immunology - Clinical Center of Serbia - Belgrade - Serbia - Faculty of Medicine - University of Belgrade - Belgrade, Serbia , Raskovic, Sanvila Clinic of Allergy and Immunology - Clinical Center of Serbia - Belgrade - Serbia - Faculty of Medicine - University of Belgrade - Belgrade, Serbia
Abstract :
Takayasu arteritis (TA) is a systemic vasculitis,
affecting mainly the aorta and its branches.
Objective: To analyze the HLA class I and class II alleles in patients
with TA and explore their relationship with clinical and demographic
characteristics, and potential significance in prognosis.
Methods: Twenty-five, unrelated TA patients were genotyped for
HLA-A, HLA-B, HLA-C, HLA-DRB1, and the HLA-DQB1 loci.
The frequencies of the HLA-A, HLA-B, and the HLA-DRB1 were
compared with a control group of 1992, while the HLA-C and the
HLA-DQB1 were compared with a group of 159 healthy, unrelated
individuals.
Results: Among TA patients, 5/25 (20%) were identified as the
HLA-B*52 carriers. There was a significant difference in the
HLA-B*52 allele frequency in the TA patients (10%) compared with
the healthy controls (1.2%). Moreover, presence of the HLA-B*52
was associated with significantly earlier disease onset, more
severe clinical presentations, and a poorer response to treatment.
The HLA-C*03 was detected in 32% of patients and was present
exclusively in those with a clinically mild form of the TA, indicating
a putative protective effect.
Conclusion: These findings indicate that the HLA-B*52 allele
contributes to a higher susceptibility to the TA whereas the
HLA-C*03, can be a protective factor in the TA.
Keywords :
Biomarkers , Immunogenetics , HLA , Vasculitis , Takayasu arteritis
