Title of article :
Choline Chloride-Oxalic Acid as a Deep Eutectic Solvent Promoted Synthesis of Aroylamido Coumarin Derivatives in Excellent Yields
Author/Authors :
Asadi, Hamed Department of Chemistry - Islamic Azad University Mahshahr Branch, Mahshahr , Anaraki-Ardakani, Hossein Department of Chemistry - Islamic Azad University Mahshahr Branch, Mahshahr , Torabi, Parviz Department of Chemistry - Islamic Azad University Mahshahr Branch, Mahshahr , Taheri, Narges Department of Chemistry - Islamic Azad University Mahshahr Branch, Mahshahr
Abstract :
An efficient and green protocol for synthesis of title compounds has been achieved via a one pot,
three component reaction of 4-hydroxycoumarin or 4-hydroxy-6-methylpyran-1-one, aryl glyoxals
and amides in choline chloride/oxalic acid as a deep eutectic solvent (DES) has been described. The
DES system offers advantages in terms of environmentally benign, biodegradable, short reaction
times, high yield and the use of safe and inexpensive components. DES can be easily recovered and
can be reused for other runs without any reduction in the activity.
Keywords :
Choline chloride , Aryl glyoxal , Deep eutectic solvents , Oxalic acid
Journal title :
Quarterly Journal of Applied Chemical Research (JACR)
