Title of article :
Catalyst free synthesis of indole derivatives via multicomponent reaction of aniline under solvent-free conditions
Author/Authors :
Ghasemian Dazmiri, Mahboubeh Department of Chemistry - Faculty of Sciences - Babolsar University, Mazandaran , Ghasemi, Narges National Petrochemical Company (NPC) - petrochemical Research and Technology Company - Arak Center, Arak , Noushin, Annataj Department of Chemistry - Islamic Azad University Gorgan Branch, Gorgan
Abstract :
Protonation of the highly reactive 1:1 intermediates produced in the reaction between alkyl(aryl) isocyanides and dibenzoylacetylene by isatin, leads to vinylnitrilium cations, which undergo carbon-centered Michael type addition with the conjugate base of the NH-acid to produce highly functionalized indole-2,3-diones.
Keywords :
Activated acetylenic compounds , Aniline , Alkyl(aryl) isocyanides
Journal title :
Iranian Journal of Organic Chemistry
