Synthesis and characterization of a new poly (Lactic Acid)/ copper oxide/ tranexamic acid nanofibrous nanocomposite as an effective textile for wound healing process

Chronic wounds represent notable clinical problems and even impose a massive financial burden on health care systems. Textile dressings for wound care are often made up of various materials, having remarkable properties, which can help enhance wound healing process. Polylactic acid has been recognized as a useful medicine in a wide range of hemorrhagic conditions such as surgeries and chronic wounds. The present study was to describe the development of novel wound dressings of polylactic acid (PLA) nanofibers loaded with CuO NPs and TXA. The structure of the PLA/CuO/TXA nanofibrous nanocomposites (NCs) was further confirmed by the field emission scanning electron microscopy (FESEM), the energy dispersive X-ray (EDX) analysis, and the Fourier-transform infrared spectroscopy (FTIR). The antibacterial efficiency was then evaluated using both Gram-negative and Gram-positive bacteria. Besides, in vitro cytotoxicity and in vivo wound healing activity were assessed. The study results revealed that the NCs concerned not only inhibited bacterial growth but also demonstrated excellent proliferation and viability for fibroblastic cells (FCs) in injured skin.