Title of article :
A multicomponent one-pot synthesis of thiazole derivatives under solvent free conditions using Fe3O4/ZnO nanocatalyst
Author/Authors :
Sharifi, Samaneh Sadat Department of Chemistry - Faculty of Sciences - Sistan and Baluchestan University, Sistan and Baluchestan , Ghasemian Dazmiri, Mahboubeh Department of Chemistry - Mazandaran University, Babolsar , Ghasemi, Narges National Petrochemical Company (NPC) - petrochemical Research and Technology Company, Arak
Abstract :
An efficient and convenient procedure has been developed for the synthesis of thiazole derivatives by one-pot condensation reaction of isothiocyanates, thiourea and ethyl bromopyruvate under environmentally solvent free conditions. The ability of some synthesized compounds to scavenge the DPPH radical was measured and the results proved this observation. Moreover, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. The obtained results of disk diffusion test showed that compound 4a-4d prevented the bacterial growth.
Keywords :
1,3-Thiazole , Isothiocyanate , Ethyl bromopyruvate , Tetramethyl thiourea , Ammonium thiocyanate , Fe3O4/ZnO nanoparticles , Multi-component reaction
Journal title :
Iranian Journal of Organic Chemistry
