Copper Nanoparticles Stabilized By Reduced Graphene Oxide as a Probe For Flectrochemical Determination of Acyclovir

The electro-oxidation of acyclovir (ACV) was studied using synthesized Cu nanoparticles stabilized by reduced graphene oxide (Cu/RGO) modified carbon paste electrodes. In this work, leaf extract of rosemary (Rosmarinus officinalis) used as a reducing and stabilizing agent for biosynthesis of copper nanoparticles. The Cu/RGO nanocomposite was authorized by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR) spectroscopy, Scanning electron microscopy (SEM), and Transmission electron microscopy (TEM). In an alkaline solution, the electrochemical performance of Cu/RGO was checked and afterward utilized to make a modified carbon paste electrode to study the electrocatalytic oxidation of acyclovir, compared to copper modifier only. Two used methods for surveying of the oxidation reaction were cyclic voltammetry and chronoamperometry. The limit of detection for modified electrode was obtained 0.63 μM. Furthermore, the rate constant of the electrocatalytic oxidation of acyclovir was (1.80 ± 0.03) ×105 cm3mol s and the electron-transfer coefficient was (4.00 ± 0.05) ×10 6 Cm2