Anion-Doped Overoxidized Polypyrrole/Multiwalled Carbon Nanotubes Modified Glassy Carbon Electrode as a New Electrochemical Sensing Platform For Buprenorphine Opioid Drug

A novel Buprenorphine (BPR) sensor is fabricated based on nanocomposite film of benzene-1,3-disulfonate anion doped overoxidized polypyrrole/multiwalled carbon modified glassy carbon electrode. The carbon nanotubes were drop-casted on bare electrode, and then thin layer of benzene-1,3-disulfonate-doped overoxidized polypyrrole formed electrochemically on it. Effect of experimental conditions involving supporting electrolyte pH, carbon nanotubes suspension drop size, and the number of potential cycles in overoxidized polymerization were optimized by monitoring the voltammetry responses of the modified electrode. Then the optimized modified electrode was used for electrochemical sensing of BPR by differential pulse voltammetry, which exhibited a linear growth with high sensitivity in anodic peak currents at the BPR concentration range of 0.06-40 μM, and a detection limit of 28 nM. Finally, the determination of BPR in urine real samples was performed by the new sensor and satisfactory results obtained.