Author/Authors :
Ghaderi, Bayazid Department of Internal Medicine - Faculty of Medicine - Kurdistan University of Medical Sciences, Sanandaj , Amini, Sabrieh Department of Biology - College of Science - Islamic Azad University, Sanandaj , Maroofi, Farzad Department of Biology - College of Science - Islamic Azad University, Sanandaj , Jalali, Chiya Department of Biology - College of Science - Islamic Azad University, Sanandaj , Javanmardi, Mitra Department of Biology - College of Science - Islamic Azad University, Sanandaj , Roshani, Daem Department of Epidemiology and Biostatistics - Faculty of Medicine - Kurdistan University of Medical Sciences, Sanandaj , Abdi, Mohammad Department of Clinical Biochemistry - Faculty of Medicine - Kurdistan University of Medical Sciences, Sanandaj
Abstract :
Background: B cell chronic lymphocytic leukemia is one of the most frequent hematologic malignancies in the world. Cellular
surface CD markers and serum Beta-2-microglobulin may be used as a prognostic tool in CLL patients.
Objectives: In the present study we introduce serum adenosine deaminase as a diagnostic marker in CLL.
MaterialsandMethods: Blood sampleswere collected from B-CLL and healthy subjects. White blood cell, red blood cell and platelet
count and blood Erythrocyte sedimentation rate was recorded and serum Beta-2-microglobulin, Lactate dehydrogenase and total
ADA enzyme activity were determined.
Results: Serum ADA activity was significantly higher in patients group than that of controls. ADA had a significant and direct correlation
with B2M, WBC, LDH and ESR. However, there was not any relation between ADA and the stages of disease. Diagnostic cut-off,
sensitivity and specificity of the serum ADA test were 27.97 U/L, 91% and 94%, respectively.
Conclusions: A higher ADA activity in patients group and its correlation with CLL markers were seen in our study. High diagnostic
value of serum ADA in our study suggests that it might be considered as a useful screening tool among the other markers in CLL.
Keywords :
Deaminase , Beta-2-Microglobulin , Chronic Lymphocytic Leukemia , Diagnostic Value
