Author/Authors :
mohamadian, niloufar islamic azad university, kermanshah branch - young researchers and elite club, kermanshah, iran , seyedmoradi, mehdi islamic azad university, kermanshah branch - young researchers and elite club, kermanshah, iran , izadi, babak kermanshah university of medical sciences - molecular pathology research center, imam reza hospital, kermanshah, iran , amirian, farhad kermanshah university of medical sciences - molecular pathology research center, imam reza hospital, kermanshah, iran , ramezani, mazaher kermanshah university of medical sciences - molecular pathology research center, imam reza hospital, clinical research development center - department of molecular pathology, kermanshah, iran
Abstract :
chronic myeloid leukemia (cml) is a clonal myeloproliferative neoplasm and one of the main subtypes of leukemia that mainly affects adults. the incidence of cml increases slowly with age until the middle of the fourth decade, and then it rises rapidly. anemia, splenomegaly, and constitutional symptoms are the most common signs and symptoms at presentation. here we report a 27-year-old man with bone pain and generalized abdominal pain. he also had weight loss because of anorexia and easy satiety. the qualitative probe-based real-time pcr (qrt-pcr) result was positive for bcr-abl1 (t9:22) p210 mutation. the patient was treated with imatinib, the standard first-line treatment for cml, and showed clinical improvement. his pain also decreased, and he was discharged in good condition.
Keywords :
bone pain , chronic myeloid leukemia , cml , weight loss
