Author/Authors :
maleki dizaj, solmaz tabriz university of medical sciences - student research committee, tabriz, iran , sharifi, simin tabriz university of medical sciences - dental and periodontal research center, tabriz, iran , shahi, shahriar tabriz university of medical sciences - dental and periodontal research center, tabriz, iran , montazersaheb, soheila tabriz university of medical sciences - molecular medicine research center, tabriz, iran , salatin, sara tabriz university of medical sciences - dental and periodontal research center, tabriz, iran , ahmadian, elham tabriz university of medical sciences - kidney research center, tabriz, iran , khezri, khadijeh urmia university of medical sciences - deputy of food and drug administration, urmia, iran , rahbar saadat, yalda tabriz university of medical sciences - kidney research center, tabriz, iran , dalir abdolahinia, elaheh tabriz university of medical sciences - research center for pharmaceutical nanotechnology, biomedicine institute, tabriz, iran , ghavimi, mohammad ali tabriz university of medical sciences - faculty of dentistry - department of oral and maxillofacial surgery, tabriz, iran
Abstract :
the main goal of this study was to gather the most critical bioactivities of curcumin, followed by the most essential concerns in its clinical usage and the challenges and potential for its use in modern medical studies. the conducted clinical studies on curcumin showed an effective anti-inflammatory and anti-cancer agent. the search results also revealed that curcumin has poor systemic bioavailability. then, designing new methods to improve its bioavailability has always been interesting. other conditions, such as neurodegenerative disease, cardiovascular disease, and diabetes, should be the subject of additional clinical research in the future. besides, new procedures, such as adjuvants, drug delivery systems, and structural changes should be used in clinical trials of curcumin.
Keywords :
curcumin , clinical trials , anti , inflammatory , anti , cancer , drug delivery systems
