Title of article
anticancer activity of new 3-secondary amine derivatives containing fused rings of the imidazopyridine
Author/Authors
hattab, ahmed university of baghdad - college of sciences - department of chemistry, baghdad, iraq , al-lami, naeemah university of baghdad - college of sciences - department of chemistry, baghdad, iraq , wadi, jaafar suhail al-rafidain university - college of pharmacy - department of pharmacology, baghdad, iraq
From page
222
To page
231
Abstract
l2 promoted one-pot protocol was suggested previously for the synthesis of 2-aryl-3-(pyridine-2- ylamino)imidazo[1,2-a]pyridine from 2-aminopyridine with different substituted acetophenone for the synthesis of secondary amine derivatives (a1-a6) compounds. after that, the secondary amine derivatives are reacted with propargyl bromide producing propargylamines (b1-b6) compounds. all synthesized compounds were characterized via ft-ir spectroscopy, some of which were characterized by 1h-nmr spectroscopy and ^13c-nmr spectroscopy. two of imidazo(1,2-a) pyridine derivatives were tested for cytotoxic activity against leukaemia cancer using mtt assay.
Keywords
one , pot , sec.amine imidazo(1 , 2 , a)pyridine , propargyl derivatives , anti , cancer activity
Journal title
Eurasian Chemical Communications
Journal title
Eurasian Chemical Communications
Record number
2704902
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