Author/Authors :
saadat, maryam semnan university of medical sciences - faculty of medicine - department of anatomical sciences, semnan, iran , malekloo, roya semnan university of medical sciences - faculty of medicine - department of physiology, semnan, iran , davoodi, marzieh shiraz university of medical sciences - student research committee, shiraz, iran , afraz, elham sadat semnan university of medical sciences - school of dentistry - department of oral medicine, semnan, iran , vaez, aysan semnan university of medical sciences - student research committee, semnan, iran , asadi, ilia semnan university of medical sciences - student research committee, semnan, iran , falahati, ali mohammad hormozgan university of medical sciences - faculty of medicine - department of medical genetics, bandar abbas, iran , safarbalou, asal mazandaran university of medical sciences, ramsar campus, sari, iran , moradi-kor, nasrollah institute for intelligent research - international center for neuroscience research, tbilisi, georgia
Abstract :
this study evaluated the beneficial effects of quercetin nano-phytosome on inflammatory parameters in multiple sclerosis. the animals were divided into five groups, including control, 150 quercetin, 300 quercetin, 150 and 300 nano-phytosome of quercetin. at the end of the study, serum levels of granulocyte- macrophage colony stimulator (gmcsf), interleukin 1β (il1β), interleukin 2 (il2), interleukin 6 (il6), interleukin 10 (il10), interleukin 17 (il17), interleukin gamma (ifnγ) and tumor necrosis factor alpha (tnfα) were determined. the results showed that administration of quercetin and its nano-phytsome significantly decreased the levels of il-1β, il-2, il-6, il-17, ifn-γ, tnf-α and gm-csf and increased il-10 in comparison to the control group. the treated animals with nano-phytsome significantly decreased il-2, il-1β, il-17, il-6, ifn-γ, tnf-α and gm-csf and increased il-10 compared with quercetin group. quercetin nanophytosomes can be used to effectively improve inflammation. we recommend using quercetin nanophytosomes to reduce inflammation in patients with multiple sclerosis.
Keywords :
cytokines , quercetin , nano , phytosome , mice , tnf , α
