hba1c in polycystic ovary syndrome as the cardiac risk assessment

objective: polycystic ovary syndrome (pcos) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. these conditions may lead to the risk of insulin resistance (ir), type 2 diabetes, obesity, and cardiovascular disease. these conditions are related to pcos complications hence our aim was to study and investigate the relationship between high-sensitivity c - reactive protein (hs-cpr) level and glycosylated hemoglobin (hba1c) level in pcos patients. materials and methods: female patients visiting the obstetrics and gynecology outpatient department (opd), aged between 19 and 45 years with a body mass index (bmi) of 25 to 29 kg/m2. the individuals fulfilling the national institute of health (nih) criteria for pcos; including amenorrhea or oligomenorrhea and had been clinically diagnosed with hyperandrogenism were served as subjects. results: two hundred and ten individuals with hba1c of 5.4% have a higher risk of cardiovascular disorders. the study showed the association between increased cardiac risk as measured by hs-crp and patients with normal hba1c values with a sensitivity of 77.2% and specificity of 75.99%. the hba1c cutoff value can be used in the pcos patients to assess the cardiac risk due to association of hba1c cut off value with false positivity rate of 15.24%. conclusion: in pcos patients with chronic low-grade inflammation, ir, and the degree of inflammation associated with hba1c value was observed.