Respiratory Syncytial Virus in Lower Respiratory Tract Infections

Objective: Acute lower respiratory infections lead to high morbidity and mortality rates in children from developing countries. The aim of this study was to look into the extent of respiratory syncytial virus infections in children with special reference to the role of specific immunoglobulins in protection against infection as well as the association with bacterial pathogens.Material Methods: Nasopharyngeal aspirates were tested for respiratory syncytial virusantigen by enzyme immunoassay and IgA antibodies by single radio immunodiffusion test. Viralculture on HEP-2 cell system and bacterial culture was done. Sera were tested for detection ofantibodies to respiratory syncytial virus by indirect fluorescent antibody test. Antigens ofstreptococcus pneumoniae and haemophilus influenzae were detected in serum and urine bylatex agglutination assay.Findings: Incidence rates of acute lower respiratory infections were highest in infants;bronchiolitis and bronchopneumonia being the main contributors. Respiratory syncytial virusinfection was found in 27.08% of the cases.Conclusion: Secretory IgA antibodies level was found to be a good indicator of respiratorysyncytial virus infection as seen by the significantly higher levels in cases as compared to bothnon respiratory syncytial virus cases and controls.