Author/Authors :
Patil, Shreekant M P.G. Department of Studies in Chemistry - Karnatak University, Dharwad-580003, India , Bagoji, Atmanand M P.G. Department of Studies in Chemistry - Karnatak University, Dharwad-580003, India , Konnur, Santosh B P.G. Department of Studies in Chemistry - Karnatak University, Dharwad-580003, India , Gokavi, Naveen M P.G. Department of Studies in Chemistry - Karnatak University, Dharwad-580003, India , Nandibewoor, Sharanappa T P.G. Department of Studies in Chemistry - Karnatak University, Dharwad-580003, India
Abstract :
Electro-analysis of orphenadrine (ORD) by graphene modified glassy carbon electrode (GPN/GCE) was studied using cyclic voltammetric and linear sweep voltammetric (LSV) techniques. The variation of the current with pH, concentration and scan rate was investigated to optimize the experimental condition for determination of ORD. The electrochemical behavior of the ORD at GPN/GCE was a diffusion-controlled process. A probable electro oxidation mechanism was proposed. Under the optimal conditions, the anodic peak current was linearly proportional to the concentration of ORD in the range from 0.03-0.37 μg/mL with a limit of detection 8.6×10-4 μg/mL for LSV. This method was applied for quantitative determination of ORD levels in urine as real samples. Further interference study was also carried with some common interfering substances.
Keywords :
Orphenadrine , Voltammetry , Graphene , Glassy carbon electrode , Oxidation
