Electro-spinning of Cellulose Acetate/Au, Ag, Cu and Polyvinyl Acetate/Au, Ag, Cu Nanofibers for Wound Healing Applications

One the most important property of a wound dressing is its anti-bacterial performance. Electrospun nanofibers showing great promise for fabricating nanostructured materials might help to wound dressing and skin engineering applications. The present study aimed to investigate and compare the wound healing potential of cellulose acetate (CA) nanofiber containing gold, silver, and copper also poly vinyl acetate (PVAc)/Au, PVAc/Ag and PVAc/Cu composite nanofibers. The samples with efficient antimicrobial capability was prepared via an electrospinning process. The comparison between these samples is aimed at selecting the best composite nanofibers for wound healing applications. For better comparison also aluminum and zinc nanoparticles were prepared by ball milling method, also amino-modified multiwall carbon nano tube were added to polymeric matrixes. Results approve gold, silver and copper have better antibacterial activities and we prepared their polymeric nano fibers composites. Various samples shows different morphology, structure, enhanced blood clotting ability and cell attachment as well as antimicrobial activity. Optimized combinations the samples were characterized by X-ray diffraction (XRD) pattern, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FT-IR).