Title of article :
Graphene Oxide as a Nanocarrier for Controlled Delivery of Indole
Author/Authors :
Sadeghipour, Yasin Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Hafez Ghoran, Salar Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Shafiee, Mostafa Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Mousavi, AmirHossein Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Dehghani, Fatemeh Sadat Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Amani, Ali Mohammad Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran
Abstract :
Regarding the specific physiochemical and biomedical properties of graphene oxide (GO), it has been a long time that experts have preferred anticancer drug cocktails to single drugs. Given that the former may develop a more balanced molecular basis for recent chemotherapeutic strategies. In this study, graphene oxide was investigated as a bioavailable nanocarrier for indoles. The synthesized components were characterized using Fourier transform infrared (FTIR), X-ray diffraction (XRD), UV–Vis spectroscopies, and scanning electron microscopy (FE-SEM) techniques. Interestingly, maximum drug loading efficiency was achieved in the neutral media (pH=7). The release analysis in different media revealed higher rate in both acidic and basic media than in neutral media. However, the total loaded drug was released in less than 80 minutes in all the systems prepared. The MTT assay results toward mesenchymal stem cells exhibited a desirable biocompatibility of GO-indole and GO. Taken together, the prepared GO-indole has suitable drug loading efficiency.
Keywords :
Bioavailability , Drug delivery , Graphene oxide , Nanocarrier , pH sensitive
Journal title :
Journal of NanoStructures
