Effect of Free Prodigiosin Pigment and Mixed Prodigiosin With TiO2 Nanoparticles in Some Viable Organs of White Mice

The study evaluated the effect of TiO2 NPs mixed with pigment on liver and kidney weight. Liver weight in G1, which is administrated with low dose of prodigiosin decreased significantly compared to liver weight in control group. No significant differences were found in kidney weight between the study groups in comparison with the control. The results also, showed highly significant increase in the level of GOT enzyme in G3, G4, G5 and G. This may confirm the effect of TiO2 NPs in restricting the prodigioisin effect and increasing its toxicity. All the study groups showed highly significant increase in urea level when compared to its level in the control group. G1, which is administrated with low dose of prodigiosin showed the highest urea levels among other groups. Same thing about GPT enzyme level, in G1 and G2 become less in a significant way than its level in the control group. The cytotoxic effects of TiO2 NPs increased when the dose was raised, according to the results of this investigation. However, the presence of Prodigiosin inhibits the activity of nanoparticles and reduces their negative effects in essential organs (liver and kidney).