Total Iron Binding Capacity (TIBC), free Iron , Ceruloplasmin,Transferrin and ferritin concentration, in pregnant women with pre-eclampsia

Background: Preeclampsia is one of the most important complications of pregnancy that is associated with increased morbidity and mortality. The evidence of increased oxidative stress due to endothelial dysfunction in preeclampsia has been well established. The increased oxidative stress is catalyzed in the presence of free transitional metals. Therefore, the relationship of iron status with preeclampsia was under investigation. The objective of the study was to compare Total Iron Binding Capacity (TIBC), Iron ,ceruloplasmin,Transferrin and ferritin concentration, in preeclamptic and healthy pregnant women, and to investigation the relation between these factors and preeclampsia. Method:Blood samples were collected from 40 pregnant women diagnosed as preeclampsia and 30 normal pregnant females at the hospital of Obstetrics and Gynecology between February 2012 and January 2013. We recorded TIBC count, Iron concentration, serumceruloplasmin, ferritinand Transferrin levels in both groups. Result: Mean serum iron in preeclamptic group was 97.0 ± 7.83, while 94.35± 11.81in normal group (p≤0.01). Similarly, mean serum TIBC concentration in normal pregnant and preeclamptic women were 319.65± 32.35 and 292.3 ±30.86, respectively (p≤0.01). The mean serum ferritin was 0.33± 0.056 in preeclamptic women and in normal pregnant women was0.29±0.039,significant differences were found among ceruloplasminconcentration in both groups, while the mean Transferrin in preeclamptic and in normal pregnant women were 204.61 ± 21.60584 and 223.75 ±22.64877, respectively. In conclusion, ischemic placental tissue may be a primary source of potentially toxic iron in preeclampsia and the released iron species may contribute to the etiology and endothelial cell injury, which may be abated by antioxidant supplementation.