Assessment of Thrombospondin-1 Level in Type II Diabetic Patients

The study is intended to asses serum levels of Thrombospondin-1, fasting blood glucose in type 2 diabetic patients, also correlation between Thrombospondin-1 in both males and females. The study was conducted on randomly selected 65 type 2 diabetic patients (34 males and 31 females) attending the diabetes mellitus center in Al-Sadder Teaching City in Al- Najaf province , Iraqi and a group of 24 apparently healthy subjects (12 Males and 12 Females) were included as a control group . The Study was carried out from August 2013 to February 2014.The patients age was ranging from 35 to 64 years old. The results indicated a significant increase (p 0.05) in serum FBG and TSP-1 levels in diabetic patients in comparing with healthy groups. The results also revealed no significant differences (p 0.05) in serum TSP-1 levels between males and females in both patients and healthy groups, while the results of FBG levels significantly (p 0.05) increase in females than males in both patients and healthy groups. The results have been shown significant positive correlation (P 0.05) between TSP-1 and FBG in (males and females), males, females DM patients. The present study concluded that Thrombospondin-1 were marker for detection and diagnosis of diabetic patients type 2.