Title of article :
Solubilization Methods for Paclitaxel and Docetaxel: An Overview
Author/Authors :
Pourkarim ، Fariba Student Research Committee, Faculty of Pharmacy, Drug Applied Research Center - Tabriz University of Medical Sciences , Rahimpour ، Elaheh Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Food and Drug Safety Research Center - Tabriz University of Medical Sciences , Alvani ، Sima Biotechnology Research Center, Immunology Research Center - Tabriz University of Medical Sciences , Jouyban ، Abolghasem Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company - Tabriz University of Medical Sciences
Abstract :
Cancer is still a serious disease with high incidence over the past decades. Many anticancer drugs are discovered and used to treat cancer, among them, taxanes such as paclitaxel and docetaxel have high lipophilicity and low aqueous solubility which is further magnified considering the strong need for administering them by intravenous infusion. Currently, the poor water-solubility of taxanes is improved by prodrug formation, conjugation, inclusion complexation, micellar solubilization and liposome-based formulations. Recent achievements for solubilization of taxanes are reviewed and critically discussed regarding their pharmaceutical and chemical applications.
Keywords :
Docetaxel , Paclitaxel , Poor water , solubility , Solubilization methods , Taxanes
Journal title :
Pharmaceutical Sciences
Journal title :
Pharmaceutical Sciences
