Title of article :
Is There any Alternative Receptor for SARS-CoV-2?
Author/Authors :
Shahriari Felordi ، Mahtab Department of Regenerative Medicine - Cell Science Research Center - Royan Institute for Stem Cell Biology and Technology , Memarnejadian ، Arash Sernova Corp , Najimi ، Mustapha Laboratory of Pediatric Hepatology and Cell Therapy - Institute of Experimental and Clinical Research (IREC) , Vosough ، Massoud Department of Regenerative Medicine - Cell Science Research Center - Royan Institute for Stem Cell Biology and Technology
Abstract :
Angiotensin-converting enzyme II (ACE2) in association with type II transmembrane serine protease (TMPRSS2) is considered the main receptor of SARS-CoV-2. However, considering the clinical complications of COVID-19 in different organs, there is no strong association between the abundance of ACE2/TMPRSS2 co-expression and clinical features of the disease and the severity of complications. Since SARS-CoV-2 affects certain organs that lack or have low expression of ACE2/TMPRSS2, it may be possible that the virus employs other receptors for colonization and entry. Based on recent studies, glucose-regulated protein 78 (GRP78) can be a potential alternative receptor for SARS-CoV-2 entry. In this letter, supporting evidence proposed GRP78 as an alternative receptor in SARS-CoV-2 infection.
Keywords :
Angiotensin , Converting Enzyme II , COVID , 19 , Endoplasmic Reticulum Stress , HSPA5 , SARS , CoV , 2
Journal title :
Cell Journal (Yakhteh)
Journal title :
Cell Journal (Yakhteh)
