Study of some physical changes of a binary combination of a drug Amphotericin B with Cetyl Trimethylammonium bromide (CTAB)

The research included studying the effectiveness of Amphotericin B with cactus aloe vera extract for its therapeutic properties by studying the physical changes with the surfactant active substance which has the ability to form thread-like micelles, and with the drug Amphotericin B in which the mixture of the surface-active substance CTAB with the drug Amphotericin B at temperatures (283.15, 293.15, 310.15, and 323.15 K) and it was found that the highest value of viscosity was at (4:6), at 6 mL of CTAB surfactant and 4 mL of Amphotericin B, from 3% wt of CTAB and 0.02 g of Amphotericin B indicating the formation of filamentous micelles. The research also included studying the effect of the plant extract of aloe vera in different sizes (1, 2, 3, and 4) mL and at different temperatures. The thermodynamic functions were calculated and the results were clarified. The formation of worm-like micelles was increasing by maximizing the size of the plant extract of aloe vera as a result of interference with the composition of micelles and the formation of hydrogen bonds with the polar aggregates of the surfactant molecule. The biological effectiveness of the mixture was confirmed, The results showed that the sample mixture (A) was effective for both killing and inhibiting the growth of (Basillus pumilus) bacteria with inhibitory diameters (12.3, 12.5 and 14.7 mm), which appeared in the form of halos around the drilling area and were distinct from the culture medium inside the dish, while the inhibitory diameters were biological (Nystatin) (12.3, 12.3, and 12.8 mm), as it is noted that the sample mixture (A) has an effectiveness in killing Basillus pumilus more than the effectiveness of the antibiotic (Nystatin) itself, as these results are significant and excellent.