Author/Authors :
Dehghani ، Mehdi Department of Hematology and Medical Oncology - Hematology Research Center - Shiraz University of Medical Sciences , Khajeh ، Anush Department of Hematology and Medical Oncology - Shiraz University of Medical Sciences , Vojdani ، Reza Department of Hematology and Medical Oncology - Hematology Research Center - Shiraz University of Medical Sciences , Sanei ، Mozhdeh Internal Medicine Department, Department of Hematology and Medical Oncology - Shiraz University of Medical Sciences , Keshavarz ، Pedram Department of Radiology - Medical Imaging Research Center - Shiraz University of Medical Sciences , Namdari ، Nasrin Department of Hematology and Medical Oncology - Shiraz University of Medical Sciences
Abstract :
Background: Studies conducted in recent years have proposed a protective effect of vitamin D3 (VitD3) against various types of cancers. Thus, in this research, we investigated the serum levels of VitD3and its relation with prognostic clinical factors in chronic lymphocytic leukemia (CLL). Method: In this cross-sectional study, 86 CLL patients were investigated for a one-year period and evaluated for the relationship between Vit D3serum levels, Rai stages, age, gender, and pathological factors. A control group was added to the study in order to compare the VitD3 levels of CLL patients with that of the normal population. Results: The mean serum VitD3level in CLL patients was 29.76 ± 18.75 ng/ml, and most of the patients were in stage I and II. There was no significant association between age, sex, and Rai stages of CLL with VitD3 level. Except for splenomegaly (P 0.001), the leukemia-related phenotypes, complications, and prognostic factors had no meaningful association with VitD3 (P 0.05) level. VitD3 serum level was meaningfully different between case and control groups (P 0.001). Conclusion: In the current research, there was no significant relationship between VitD3serum levels and investigated variables, except splenomegaly; these findings are in concordance with other studies
