Title of article :
Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview
Author/Authors :
Kasali ، Félicien Mushagalusa Pharm-Biotechnology and Traditional Medicine Center of Excellence - Mbarara University of Science and Technology , Tuyiringire ، Naasson Pharm-Biotechnology and Traditional Medicine Center of Excellence - Mbarara University of Science and Technology , Peter ، Emanuel L. Pharm-Biotechnology and Traditional Medicine Center of Excellence - Mbarara University of Science and Technology , Ahovegbe ، Lucrèce Y. Pharm-Biotechnology and Traditional Medicine Center of Excellence - Mbarara University of Science and Technology , Ali ، Muhammad Shaiq H.E.J. Research Institute of Chemistry, International Centre for Chemical Biological Sciences - University of Karachi , Tusiimire ، Jonans Department of Pharmacy - Faculty of Medicine - Mbarara University of Science and Technology , Ogwang ، Patrick Engeu Department of Pharmacy - Pharm-Biotechnology and Traditional Medicine Center of Excellence, Faculty of Medicine - Mbarara University of Science and Technology , Kadima ، Justin Ntokamunda Department of Pharmacy - Faculty of Pharmaceutical Sciences and Public Health - Official University of Bukavu , Agaba ، Amon Ganafa Department of Pharmacology and Therapeutics - Faculty of Medicine - Mbarara University of Science and Technology
Abstract :
Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of the chemical composition supporting the multiple pharmacotherapeutic indications and dietary values of this plant through evidence-based studies from Google Scholar, PubMed/Medline, SciFinder, Science Direct, Scopus, the Wiley online library, and Web of Science. The literature mentions at least 40 compounds isolated from different parts; others are still under investigation. High yields in carotenoids, amino acids, minerals, vitamin C, vitamin E, and essential fatty acids have healthy nutritional benefits. Various phytoconstituents, particularly withanolides, exhibit anti-carcinogenic, anti-inflammatory and antidiabetic potentials, as well as cardiovascular and liver protective effects. Prospective studies reveal that the leaves would also provide various beneficial bioactive chemicals worth being isolated. However, clinical evidence-based studies are seldom. Therefore, adequate pharmaceutical formulations and more in- depth controlled clinical trials are needed to fill the gap.
Keywords :
Physalis peruviana , Phytochemicals , Bioactivity , Pharmacological mechanisms , Therapeutic uses
Journal title :
Journal of HerbMed Pharmacology
Journal title :
Journal of HerbMed Pharmacology
