Correlation of a well-known genetic variation in one-carbon metabolism pathway with breast cancer susceptibility in Iranian population

The one-carbon metabolism pathway is an essential cycle in cellular reactions. Methylenetetrahydrofolate reductase is a critical gene in this pathway. This gene contains numerous variations in which the rs1801133 is considered the most common polymorphism. This study was aimed to examine the correlation of the above-mentioned genetic variation with the risk of breast cancer in the Iranian population through a meta-analysis procedure. In this search, valid electronic databases such as PubMed and Goggle scholar were used to gather eligible studies. Finally, five useful articles were included in our meta-analysis. The odds ratio (OR) and 95% confidence interval (CI) were examined by http://bioinfo.genyo.es/metagenyo online software to evaluate the strength of association values. The data from the meta-analysis illustrated that the rs1801133 genetic variation is correlated with breast cancer in TT vs. CC and TT vs. CC+CT hereditary models within Iranian women. Also, the o‎r analysis revealed that the studies with a sample size > 250 were associated with breast cancer. According to these findings, the studied single nucleotide polymorphism could be considered a molecular genetic variation for breast cancer in Iranian women.