Author/Authors :
Safarian, Mohammad mashhad university of medical sciences - Faculty of Medicine - Department of Nutrition and Biochemistry, مشهد, ايران , Vakili, Rahim mashhad university of medical sciences - Faculty of Medicine - Department of Pediatrics, مشهد, ايران , Sahebkar, Amirhossein mashhad university of medical sciences - Avicenna Research Institute - Cardiovascular Research Center, مشهد, ايران , Nematy, Mohsen mashhad university of medical sciences - Faculty of Medicine - Department of Nutrition and Biochemistry, مشهد, ايران , Dahri, Monireh mashhad university of medical sciences - Avicenna Research Institute - Cardiovascular Research Center, مشهد, ايران , Tavallaie, Shima mashhad university of medical sciences - Avicenna Research Institute - Cardiovascular Research Center, مشهد, ايران , Lotfian, Elham mashhad university of medical sciences - Avicenna Research Institute - Cardiovascular Research Center, مشهد, ايران , Khorashadizadeh, Mona mashhad university of medical sciences - Avicenna Research Institute - Cardiovascular Research Center, مشهد, ايران , Ferns, Gordon University of Surrey - Centre for Clinical Science Measurement, United Kingdom , Ghayour-Mobarhan, Majid mashhad university of medical sciences - Avicenna (Bu-Ali) Research Institute - Cardiovascular Research Center, مشهد, ايران , Ghayour-Mobarhan, Majid MUMS - Faculty of Medicine - Department of Nutrition, IR Iran
Abstract :
Objective: An immune response to heat shock proteins appears to be involved in atherogenesis. To date, there has been no report on the impact of dairy or calcium consumption on serum antibody titers to heat shock protein 27 (anti-HSP27). We have investigated whether an increase in dairy food consumption is capable of affecting serum antibody titers to heat shock protein 27 (anti-HSP27) level in children. Methods: Overweight and obese children (n=99, age: 12‐18 y, body mass index: 27-40 kg/m2) were randomized to receive a calorie restricted diet providing a 500 kcal/d deficit from totalenergy expenditure and two (n=38), three (n=26) or four (n=35) servings of dairy products/day. Serum anti-HSP27 level in addition to the serum hs-CRP and lipid profile were measured at baseline and after 12 weeks. Findings: Serum anti-HSP27 concentrations did not change significantly in any of the mentioned groups. Serum hs-CRP and lipid profile did not change significantly either, apart from a significant increase in HDL-cholesterol in the low-dairy group. Conclusion: An increased intake of dairy products does not lead to a significant change in serum anti-HSP27 level in overweight and obese children.
Keywords :
Dairy , Body Mass Index , Overweight , Obesity , Anti , HSP27 , Calcium
