Title of article :
Serum Copper Concentration in Newborns with Neural Tube Defects in Northern Iran; A Case Control Study.
Author/Authors :
Golalipour, Mohammad-Jafar golestan university of medical sciences - Gorgan Congenital Malformations Research Center - Department of Embryology, گرگان, ايران , Mansourian, Azad-Reza golestan university of medical sciences - Metabolic Research Center - Department of Biochemistry and Biochemistry, گرگان, ايران , Keshtkar, Abbas-Ali golestan university of medical sciences - Department of Community Medicine, گرگان, ايران
Abstract :
Objective: This study was conducted to determine the eventual association between copper deficiency in newborns with neural tube defects (NTD) in Northern Iran. A high prevalence of neural tube defects has been reported from this region. Methods: This hospital based case control study was carried out on 13 newborns having neural tube defects and 35 healthy controls in Northern Iran during 2005-2006. Serum copper was measured by spectrophotometery. Findings: Serum copper level in newborns with NTD and healthy normal newborns was 16.5 ((plus-minus)7.2) (mu)mol/l and 16.7 ((plus-minus)6.6) (mu)mol/l, respectively. In case group 38.5% of newborns and in control group 28.6% had copper deficiency. Logistic regression analysis showed no association between the presence of NTD and copper deficiency (OR:1.6, 95% CI=0.3-7.1, P=0.5). Conclusion: This study showed no association between NTD and copper deficiency in newborns.
Keywords :
Neural tube defects , Spina bifida , Anencephaly , Copper , Newborns
Journal title :
Iranian Journal of Pediatrics
Journal title :
Iranian Journal of Pediatrics
