Title of article :
Antiviral Vector Effects of Ivermectin on COVID-19: An update
Author/Authors :
Heidary, Fatemeh International Virtual Ophthalmic Research Center (IVORC), Texas, USA , Gharebaghi, Reza International Virtual Ophthalmic Research Center (IVORC), Texas, USA , Lateef, Mohammed Department of Rehabilitation - Shahid Beheshti University of Medical Science , Zain Alabden Mohammed, Mustafa Department of Rehabilitation - Shahid Beheshti University of Medical Science , Fawzi Hasan Alshmailawi, Sarah Department of Rehabilitation - Shahid Beheshti University of Medical Science , Alkhafaji, Kahtan Department of Rehabilitation - Shahid Beheshti University of Medical Science , Thamer Albhadili, Rafid Department of Rehabilitation - Shahid Beheshti University of Medical Science , Khalaf Abed Alhairari, Hussein Department of Rehabilitation - Shahid Beheshti University of Medical Science , Fazil Maktoof, Nagham Department of Rehabilitation - Shahid Beheshti University of Medical Science , Abbas Shafi Alkhshaymee, Magdam Department of Rehabilitation - Shahid Beheshti University of Medical Science
Abstract :
Ivermectin proposes several potentials effects, with its antimicrobial, antiviral, and anti-cancer properties. In a recently published systematic review, Ivermectin is effective on several enveloped, positive-sense, single-stranded RNA viruses such as Zika Virus, Dengue Virus, Yellow Fever Virus, West Nile Virus, Venezuelan Equine Encephalitis Virus, Chikungunya Virus, Semliki Forest Virus, Sindbis Virus, Porcine Reproductive and Respiratory Syndrome Virus, and Human Immunodeficiency Virus Type 1. Also, SARS-CoV-2 is considered as an enveloped, positive-sense, single-stranded RNA virus that was inhibited by Ivermectin in in-vitro evaluations. Although several clinical trials about the effectiveness of Ivermectin on COVID-19 are on the way, the current in vitro research is usually used in the early stages to outline new medications. Additionally, further clinical trials are required to confirm the safety and efficacy of ivermectin for human use against COVID-19 either therapeutic or preventive. We reviewed the vector effects of ivermectin on COVID-19.
Keywords :
Antiviral , COVID-19 , Ivermectin , RNA virus , Viral vector
Journal title :
Journal of Cellular and Molecular Anesthesia
