Title of article :
The Spike Protein Mutations and its Effect on SARS-CoV-2 Pathogenesis
Author/Authors :
Zandi, Milad Department of Virology - School of Public Health - Tehran University of Medical Sciences , Soltani, Saber Department of Virology - School of Public Health - Tehran University of Medical Sciences , Sanami, Samira Department of Medical Biotechnology - School of Advanced Technologies - Shahrekord University of Medical Sciences, , Rasooli, Azadeh Department of Biochemistry - Faculty of Sciences - Payame Noor University, Tehran
Abstract :
The severe acute respiratory syndrome coronavirus 2 spike (S) glycoprotein facilitates receptor binding to initiate cell entry that is the critical initial step in the infection cycle. Due to S glycoprotein's pivotal role, in this review, we pointed to show potential functional and structural consequences of S glycoprotein and its variants, which has been related with increased viral load in humans with SARS-CoV-2 infection.
Keywords :
Spike glycoprotein , COVID-19 , Mutation , SARS-CoV2 , Macromolecule
Journal title :
Journal of Cellular and Molecular Anesthesia
