Author/Authors :
Esfahanian, Fatemeh Department of Endocrinology- Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Mirabdolhagh Hazaveh, Mojgan Department of Internal Medicine - Sina Hospital - Tehran University of Medical Sciences, Tehran, Iran , Garehbagh, Laya Hooshmand Department of Endocrinology - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Falahati, Kowsar Clinical Genetics Department - National Institute of Genetic Engineering and Biotechnology, Tehran, Iran , Ataei, Mitra Clinical Genetics Department - National Institute of Genetic Engineering and Biotechnology, Tehran, Iran , Sanati, Mohammad Hossein Clinical Genetics Department - National Institute of Genetic Engineering and Biotechnology, Tehran, Iran , Jadali, Zohreh Department of Immunology - School of Public Health - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC).
Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in pe-ripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group.
Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the patho-physiology of HT.
Keywords :
Mitochondrial DNA , Hashimoto's thyroiditis , Autoimmunity , Oxidative stress
