The Effect of Probiotic Supplements on Oxidative Stress in Various Diseases: A Systematic Review

Introduction: Recently, the consumption of probiotics to decrease Oxidative Stress (OS) has been recommended. The present study aimed to assess the effect of probiotics on OS in various diseases as well as in different models in a systematic review study. Materials and Methods: Articles were searched through scientific sources such as PubMed, MEDLINE, Wiley, EMBASE, ISI Web of Knowledge and Scopus by two review authors independently. The keywords that applied to search these articles included: Probiotics, OS, Stresses, Oxidative and Stress. Results were then combined and reviewed regarding the type of study, type of disease/participants and outcomes. Results: In order to conduct this study, 19 eligible studies were investigated. The results showed that various probiotics supplements could improve OS parameters in pregnant women, patients with type 2 diabetics, Diabetic Kidney Disease (DKD) type 2, gestational diabetes mellitus, and the aging process, inflammatory factors in petrochemical workers, acute necrotizing pancreatitis, and polycystic ovary syndrome. However, no significant effect was reported on the oxidative status in patients with Rheumatoid Arthritis. Conclusions: Probiotics supplements could improve OS biomarkers in various diseases. There are still some controversies about these methods and types of probiotics supplementations. It is recommended that more studies should be conducted for a better decision.