Association of Oxidative Stress with Renal Function in Cigarette Smokers

Background and aim: Cigarette smoking is known to be associated with increased oxidative stress and renal function, both known to be associated with cardiovascular disease. The present study aimed to associate oxidative stress with kidney function in cigarette smokers. Material and methods: The present study was carried out in the department of biochemistry, Santosh medical college, Ghaziabad, National Capital Region (NCR), India. In this study, 280 subjects were enrolled, out of which 140 were smokers, and 140 were non-smokers healthy individuals. The subjects who had been smoking for two or more than two years were included. All the subjects were in 20 – 60 years of age. Results: The mean levels of blood urea (p=0.019), serum creatinine (p=0.013), urinary albumin (p 0.0001), urinary albumin creatinine ratio (uACR) (p 0.0001), Cystatin C (p=0.01) and Malondialdehyde (MDA) (p 0.0001) were increased in smokers as compared to non-smokers while the concentration of serum uric acid (p=0.02), urinary creatinine (p=0.01) and estimated glomerular filtration rate (eGFR) (p 0.0001) levels were decreased in smokers as compared to non-smokers. Malondialdehyde was negatively and significantly correlated estimated glomerular filtration rate (r=-.442, p 0.05) and positively and significantly correlated with uACR (r=0.536, p 0.01) and Cystatin C (r=0.428, p 0.05). Conclusions: The present study concluded that Smoking increases renal parameters and oxidative stress and a significant association between oxidative stress and renal parameters in smokers.