Author/Authors :
Karimi, Saeed Ophthalmic Research Center - Research Institute for Ophthalmology and Vision Science - Shahid Beheshti University of Medical Sciences, Tehran, Iran - Department of Ophthalmology - Torfeh Medical Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Arabi, Amir Department of Ophthalmology - Torfeh Medical Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Shahraki, Toktam Department of Ophthalmology - Torfeh Medical Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ansari, Iman Department of Ophthalmology - Torfeh Medical Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Safi, Sare Ophthalmic Epidemiology Research Center - Research Institute for Ophthalmology and Vision Science - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Purpose: To report a case of progressive Chiari malformation type I (CIM) in a patient with unilateral sporadic retinoblastoma (RB) treated with intra‑arterial chemotherapy (IAC) and enucleation.
Methods: A 5‑year‑old male patient with a history of RB in his left eye treated with IAC and enucleation presented to our clinic for routine
RB surveillance. Radiotherapy had not been used for the treatment of his RB.
Results: A progressive herniation of cerebellar tonsils through the foramen magnum was detected on follow‑up magnetic resonance
imaging (MRI). Brain and cervical MRI revealed no central nervous system mass, hydrocephalus, or syringomyelia. There was no history of head trauma.
Conclusion: Progressive CIM may occur in unilateral sporadic RB.
Keywords :
Chiari malformation , Chiari malformation type I , Germline , Intra‑arterial chemotherapy , Posterior fossa , Retinoblastoma , Sporadic
