Title of article :
Regenerative Medicine and Perioperative Hypoxic Organ Damage: Targeting Hypoxia-Inducible Factors
Author/Authors :
Tabashi, Soudeh Department of Anesthesiology - School of Medicine - Anesthesiology Research Center - Ayatollah Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Tajbakhsh, Ardeshir Department of Anesthesiology - School of Medicine - Anesthesiology Research Center - Ayatollah Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Dahi, Mastaneh Department of Anesthesiology - School of Medicine - Anesthesiology Research Center - Ayatollah Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Dabir, Shideh Department of Anesthesiology - School of Medicine - Anesthesiology Research Center - Ayatollah Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Vosoughian, Maryam Department of Anesthesiology - School of Medicine - Anesthesiology Research Center - Ayatollah Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Moshari, Mohammadreza Department of Anesthesiology - School of Medicine - Anesthesiology Research Center - Ayatollah Taleghani Hospital - Shahid Beheshti University of Medical Sciences
Abstract :
Regenerative medicine is defined by utilizing the body’s repair mechanisms to restore the normal function of tissues. An important perioperative issue for anesthesiologists is organ damage that is caused by hypo-perfusion mostly due to hypoxia. Our body’s response to low oxygen concentration promotes a genomic pathway to increase the level of hypoxia-inducible factors (HIFs). Regenerative medicine can help to heal damaged tissue in the perioperative period. This review introduces HIFs and their protective effect in various organs, especially during surgery, as a pioneering role of regenerative medicine to prevent perioperative complications.
Keywords :
Anesthesia , Hypoxia-Inducible Factor , Perioperative medicine , Regenerative medicine
Journal title :
Journal of Cellular and Molecular Anesthesia
